Biographie et livres de Tasuku Honjo

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Dr. Tasuku Honjo graduated from Kyoto University Faculty of Medicine in 1966 (M.D.). After obtaining his Ph.D. in Biochimistry (Dr. O. Hayaishi), he spent 4 years in the U.S.A. as a postdoctoral fellow first in Carnegie Institution of Washington (Dr. D. Brown), and then in NIH (Dr. P. Leder) where he initiated studies on immunoglobulin genes. He returned to Tokyo University as an assistant professor in 1974, and then moved to Osaka University School of Medicine as Professor of Genetics in 1979. He succeeded to Dr. O. Hayaishi after his retirement at the Department of Medical Chemistry in Kyoto University. He also served as Dean of Medical School (1996-2000 and 2004-2005), and Executive Member of Council for Science and Technology Policy, Cabinet Office (2006-2012). Currently, he is Professor of Department of Immunology and Genomic Medicine, Kyoto University, and also Chairman of Board of Directors, Shizuoka Prefectural University Corporation.
Dr. Honjo is well known for his discovery of activation-induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation. He has established the basic conceptual framework of class switch recombination starting from discovery of DNA deletion (1978) and S regions (1980), followed by elucidation of the whole mouse immunoglobulin heavy-chain locus. His contribution further extended to cDNA cloning of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain. Aside from class switching recombination, he discovered PD-1 (program cell death 1), a negative coreceptor at the effector phase of immune response and showed that PD-1 modulation contributes to treatments of viral infection, tumor and autoimmunity. In addition, he is known to be a discoverer of RBP-J, a nuclear protein that interacts with the intracellular domain of Notch in the nucleus. Notch/RBP-J signaling has been shown to regulate a variety of cell lineage commitment including T and B cells.
For these contributions, Dr. Honjo has received many awards, including the Noguchi Hideyo Memorial Prize for Medicine (1981), Imperial Prize, Japan Academy Prize (1996), Robert Koch Prize (2012), and Order of Culture (2013). He is an honorary member of the American Association of Immunologists. He has been honored by the Japanese Government as a person of cultural merits (2000). He has also been elected as a foreign associate of National Academy of Sciences, USA in 2001, as a member of Leopoldina, the German Academy of Natural Scientists in 2003, and as a member of Japan Academy in 2005.

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Molecular Biology of B Cells

Frederick Alt , Tasuku Honjo , Andreas Radbruch , Michael Reth

Academic Press

2014-10-09

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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular,...

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5 Livre(s)


Immunoglobulin Genes Frederick W. Alt , Tasuku Honjo Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells. Editeur : Academic Press Parution : 2012-12-02 PDF sans DRM 57,97 € J'achète Téléchargement immédiat Dès validation de votre commande
Negative Co-Receptors and Ligands Rafi Ahmed , Tasuku Honjo Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or... Editeur : Springer Parution : 2011-04-11 Collection : Current Topics in Microbiology and Immunology ePub 147,69 € J'achète Téléchargement immédiat Dès validation de votre commande
AID for Immunoglobulin Diversity Frederick W. Alt , Tasuku Honjo Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation... Editeur : Academic Press Parution : 2007-06-05 epub sans DRM 163,52 € J'achète Téléchargement immédiat Dès validation de votre commande
Gut-Associated Lymphoid Tissues Tasuku Honjo , Fritz Melchers Editeur : Springer Parution : 2006-10-05 Collection : Current Topics in Microbiology and Immunology PDF 147,69 € J'achète Téléchargement immédiat Dès validation de votre commande
Immunoglobulin Genes Frederick W. Alt , Tasuku Honjo The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity.The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding... Editeur : Academic Press Parution : 1995-09-27 PDF sans DRM 57,97 € J'achète Téléchargement immédiat Dès validation de votre commande

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Biographie et livres de Tasuku Honjo

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Tous les livres numériques de Tasuku Honjo en PDF et EPUB