Téléchargez le livre : Small Molecule DNA and RNA Binders

Small Molecule DNA and RNA Binders

From Synthesis to Nucleic Acid Complexes

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Éditeur :

Wiley-VCH


Paru le : 2006-03-06



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Description
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Pages
754 pages
Collection
n.c
Parution
2006-03-06
Marque
Wiley-VCH
EAN papier
9783527305957
EAN PDF
9783527605668
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
754
Taille du fichier
13036 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
327,89 €

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