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Transporters and Drug-Metabolizing Enzymes in Drug Toxicity



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Wiley


Paru le : 2021-06-29



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Description
TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY
Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources
Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences.
Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity.
Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity
Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.
Pages
528 pages
Collection
n.c
Parution
2021-06-29
Marque
Wiley
EAN papier
9781119170846
EAN PDF
9781119170914
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
528
Taille du fichier
7916 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
213,06 €
EAN EPUB
9781119170990
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
528
Taille du fichier
12360 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
213,06 €

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